原力醫學院

◆ 基本資料
   姓名：張瑞芝 Jui-Chih Chang
   地址： 500 彰化市旭光路235號 彰化基督教醫院 教學大樓7樓
   電話： +886-4-7238595 轉 4735
   Email ： 145520@cch.org.tw

◆ 現任
   彰化基督教醫院原力醫學院執行長 2018/07~迄今
   彰化基督教醫院原力醫學院組織工程研究中心研究員 2009/11~迄今
   彰化基督教醫院共同研究室 主任 2012/07~迄今 
   彰化基督教醫院原力醫學院組織工程研究中心主任 2018/07~迄今
   臺灣粒線體醫學暨研究學會理事2018~迄今

    
◆ 學歷
   國立中興大學 生命科學院 博士 2004/07~2009/10
   私立中山醫學院 營養科學研究所 碩士 2000/07~2002/07
   私立靜宜大學 食品營養系 學士 1996/07~2000/07

◆ 經歷
  彰化基督教醫院血管暨基因體研究中心研究員 2009/11~2021/05
  臺灣粒線體醫學暨研究學會理事秘書長2016/08 ~2018
  彰化基督教醫院血管暨基因體研究中心副主任 2012/07~2018/06
   大葉大學 生物資源系 兼任助理教授 2013/08~2015/08
  彰化基督教醫院再生醫學研究室主持人 2011/08~2012/07
  彰化基督教醫院粒線體醫學研究室主持人 2009/11～2011/07
  日本京都大學短期進修 2009/06～2009/09
  中興大學組織工程與幹細胞中心 雷射聚共軛焦顯微鏡操作員 2005/10~2009/10
  廣三豐富牙醫診所 生物研究室 助理研究員 2002/09~2004/03

◆ 專科學會
   臺灣粒線體醫學暨研究學會會員 、台灣幹細胞學會會員、

◆ 專長
  組織工程、粒線體醫學、神經退化性疾病學、粒線體移植、細胞生物 、奈米醫學

◆ 專利    

◆歷年計畫:
1.研發腦組織溶氧濃度與產酸率微探針感測器用以評估經鼻傳遞胜?修飾粒線體治療6-OHDA誘導巴金森氏
   症大鼠成效.(MOST 107-2320-b-371-001-MY2)科技部專題研究計畫主持人107-108
2.探討粒線體移植對於調控高糖誘導脂肪間葉幹細胞老化之影響 (108-CCH-IRP-003)彰基個人型專題研究
   108.04-109.03
3.評估鼻腦途徑移植環孢素A預處理之粒線體提升治療遺傳型巴金森氏症療效與相關致病機轉探討-以基因
   剔入細胞與小鼠為模式(MOST 109-2320-B-371-002 -)科技部專題研究計畫主持人109.08-110.07
4.研發腦組織溶氧濃度與產酸率微探針感測器用以評估經鼻傳遞胜?修飾粒線體治療6-OHDA誘導巴金森氏
   症大鼠成效  (109-CCH-MST-168)109.01-110.12
5.開發粒線體標靶細胞穿膜胜?探討其對UQCRC1 基因突變導致之巴金森神經細胞保護作用影響調控.彰基
   個人型專題研究(109-CCH IRP 019)109.06-110.05
6.發展免標定與快速檢測之電化學微流體晶片於細胞粒線體活性評估的應用(110-NCHU-CCH-01)110.04
   -111.12
7.透過移植功能正常粒線體治療巴金森氏症大鼠平台評估血漿中游離粒線體核酸表現量與氧化傷害是否可做
   為巴金森氏症治療預後指標(110-CCH-IRP-060)110.05-112.04
8.評估鼻腦途徑移植環孢素A預處理之粒線體提升治療遺傳型巴金森氏症療效與相關致病機轉探討-以基因
   剔入細胞與小鼠為模式(110-CCH-MST-176)110.01-112.12
9.追蹤鼻滴給予神經保護粒線體標靶細胞穿膜胜Penetratin 於 UQCRC1 基因突變巴金森小鼠於腦中與體內
   分布與表現(111-CCH-IRP-112)111.05-113.04
10.釐清細胞穿刺胜?Penetratin 對 UQCRC1 基因突變對巴金森大鼠神經保護之機轉(111-CCH-HCR-141)
   111.01-113.11

◆ 論文著作 (期刊論文)
1.Chang JC, Su HL and Hsu SH. The use of peptide-delivery to protect human adipose-derived 
   adult stem  cells from damage caused by the internalization of quantum dots.Biomaterials.
   2008;29:925-36
2.Chang JC, Hsu Sh and Su HL.The regulation of the gap junction of human mesenchymal stem 
   cells through the internalization of quantum dots. Biomaterials. 2009;30:1937-46. 
3.Chang JC, Hsu SH and Chen DC.The promotion of chondrogenesis in adipose-derived adult   stem
   cells by an RGD-chimeric protein in 3D alginate culture.Biomaterials. 2009;30:6265-75.
4.Hsu SH and Chang JC. Static magnetic field promoted the mineralization of rat dental pulp cells.
   Cytotechnology, 2010; 62(2):143-55.
5.Chang JC, Shou-Jen Kou, Wei-Ting Lin and Chin-San Liu. The regulatory role of mitochondria
   in oxidative  stress and atherosclerosis. World of Journal cardiology, 2010.
6.Chang JC, Lee PC, Lin YC, Lee KW and Hsu S*.Primary Adipose-Derived Stem Cells Enriched by
   Growth  Factor Treatment Improves Cell Adaptability toward Cardiovascular Differentiation in a
   Rodent Model of  Acute Myocardial  Infarction.J Stem Cells. 2011;6(1):21-37.
7.Sua SL,Wang WF,Wu SL, Chang JC, Huang CS et al. FGF21 in ataxia patients with spinocerebellar 
   atrophy and mitochondrial disease. Clinica Chimica Acta,2012;414:225-7.
8.Chang JC, Liu KH,Li YC,Kou SJ,Wei YH,Chuang CS,Hsieh M,Liu CS.Functional recovery of human
   cells harbouring the mitochondrial DNA mutation MERRF A8344G via peptide-mediated
   mitochondrial delivery. Neurosignals. 2013;21(3-4):160-73.
9.Chang JC, Liu KH, Chuang CS, Su HL, Wei YH, Kuo SJ, Liu CS. Treatment of human cells derived
   from myoclonic epilepsy and ragged red fibre (MERRF)disease by peptide-mediated
   mitochondrial delivery. Cytotherapy. 2013. 21(3-4):160-73.
10.Chang JC, Fujita S, Tonami H, Kato K, Iwata H, Hsu SH.Cell orientation and regulation of cell–
     cell  communication in human mesenchymal stem cells on different patterns of electrospun
     fibers.Biomed. Mater.2013,Oct;8(5):055002.
11.Chang JC, Liu KH, Chuang CS, Wu SL, Kuo SJ, Liu CS. Transplantation of Pep-1-labeled
    mitochondria protection against a 6-OHDA-induced neurotoxicity in rats. The Changhua Journal
    of Medicine, 2013,11:8-17.
12.Liu CS, Chang JC, Kuo SJ, Liu KH, Lin TT, Cheng WL, Chuang SF. Delivering healthy mitochondria
     for the  therapy of mitochondrial diseases and beyond.Int J Biochem Cell Biol. 2014 Aug;53:141
     -6.Epub 2014 May 16.
13.Huang PJ, Kuo CC, Lee HC, Shen CI, Cheng FC, Wu SF, Chang JC, Pan HC, Lin SZ, Liu CS, Su HL.
    Transferring Xenogenic Mitochondria Provides Neural Protection Against Ischemic Stress in
    Ischemic Rat Brains.Cell Transplant. 2016;25(5):913-27. Epub 2015 Nov 6.
14.Liu CS, Hsiao CC, Kuo CL, Chiu CM, Cheng WL, Kuo CC,  Lin LCH, Lin LC, Chang HJ,  Li HW,Deng
    LC, Chang JC, Lo LC,  Liu PT, Wei TS.Impact of Holistic Care with Tai Chi Exercise on Depressed
    Patients with Spinocerebellar Degeneration Disease-Pilot Study(全人照護及太極拳運動對於重度憂
    鬱小腦萎縮患者之影響-前驅研究)。The Changhua Journal of Medicine(彰化醫學) 2016;14:179-186
15.Chang JC, Wu SL,Liu KH, Chen YH,  Chuang CS, Cheng FC, Su HL, Wei YH,  Kuo SJ and  Liu CS .
    Allogeneic/xenogeneic transplantation of peptide-labelled mitochondria in Parkinson's disease 
    :restoration of mitochondria functions and attenuation of 6-OHDA-induced neurotoxicity.
    Transl Res. 2016 Apr;170:40-56.e3. Epub 2015 Dec 15. (SCI, 2/30, MEDICAL LABORATORY
    TECHNOLOGY).MOST 101-2314-B-371-003-MY2.
16.Chang JC, Wu SL, Hoel F, Cheng YS, Liu KH, Hsieh M, Hoel A, Tronstad KJ, Yan KC, Hsieh CL, Lin
     WY,Kuo SJ, Su SL, Liu CS. Far-infrared radiation protects viability in a cell model of Spinocerebellar
     Ataxia by  preventing polyQ  protein accumulation and improving mitochondrial function. Sci
     Rep. 2016 Jul 29;6:30436.(SCI, 7/63, MULTIDISCIPLINARY SCIENCS).
17.Hsiao CC, Chang JC, Tsao LT, Yang RC, Chen HN, Lee CH, Ching-Yuang Lin and Yi-Giien Tsai
     Correlates of Elevated Interleukin-6 and 8-hydroxy-2’-deoxyguanosine levels in Tracheal
     Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia.
     Pediatr Neonatol.2017 Feb;58(1):63-69. Epub 2016 May 30. (SCI, 70/120, PEDIATRICS).
18.Chang JC, Hoel F, Liu KH, Wei YH, Cheng FC, Kuo SJ, Tronstad KJ and Liu CS. Peptide-
     mediated delivery of donor mitochondria improves mitochondrial function and cell viability in
     human cybrid cells with the MELAS A3243G mutation.Sci Rep. 2017 Sep 6;7(1):10710. (SCI).
     MOST 103-2320-B-371-001.
19.Chang JC, Yeh CY, Chang TL, Liu KH, Soong BW, Hsieh ML, Chang T, Liu CS. In vivo and In vitro
     Studies of Mitochondrial Transplantation for the Treatment of Spinocerebellar Ataxia Type 3.The
     Changhua Journal of Medicine,2017, Nov 15:176-193. MOST 103-2320-B-371-001.
     本人為通訊作者.
20.Wu YL,Chang JC, Lin WY, Li CC, Hsieh ML, Chen HW,Wang TS, Liu CS, Liu KL .Treatment with
     Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and
     Drosophila Models of Spinocerebellar Ataxia Type3.Scientific Reports,2017, Sep 14;7(1):11641.
    (SCI).
21.Chuang CS, Chang JC,Cheng FC,  Liu KH,  Su HL, Liu CS . Modulation of mitochondrial
     dynamics by treadmill training to improve gait and mitochondrial deficiency in a rat model of
     Parkinson's disease.Life Sci. 2017 Dec 15;191:236-244(SCI).
22.Wu YL, Chang JC, Lin WY, Li CC, , Hsieh ML, Cheng HW, Wang TS,Wu WT , Liu CS, Liu KL .
     Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of
     spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Free Radic Biol Med. 2018
     Feb 1;115:309-317.Epub 2017 Dec 13. (SCI). MOST 106- 2320-B-040-025-MY3.
23.Hsiao YH, Li, CW Chang JC, Chen ST, Liu CS and Wang GJ. Chemical-Free Extraction of Functional
     Mitochondria Using a Microfluidic Device. Inventions 3.4 (2018): 68.
24.Liu SW, Chang JC, Chuang SF, Liu KH, Cheng WL, Chang HJ, Chang HS, Lin TT, Hsieh CL, Lin WY,
     Hsieh ML, Kuo SJ,   Liu CS (2018, Mar). Far- infrared Radiation Improves Motor Dysfunction and
     Neuropathology in Spinocerebellar Ataxia Type 3 Mice. The cerebellum, The Cerebellum (2018):
     1-11.
25.Chang JC, Chao YC, Chang HS, Chang HJ, Cheng WL, Lin TT, Liu CS. Feasibility of Mitochondrial
     Transplantation Via Nose-To-Brain Delivery for Treatment of Parkinson Diseases.Biomedical
     Journal of Scientific & Technical Research, 2018, Nov 11(5)-2018. (ISI, multidisciplinary).
     MOST 106-2314-B-371-007. 本人通訊作者.
26.Chang JC, Chang HS, Wu YC,Cheng WL, Lin TT, Chang HJ, Kuo SJ, Chen ST, Liu CS (2019, Jan).
     Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial
     dynamics in breast cancer. J Exp Clin Cancer Res. 2019 Jan 23;38(1):30. (SCI, Oncology
     journals).MOST 106-2314-B-310-004.
27.Su CH, Chen JW, Chen LD, Chang JC,Liu CS, Chang CCC, Wang GJ . Organic Small Molecule for
    Detection and Photodegradation of Mitochondrial DNA Mutations. J Mater Chem B. 2019 Oct
    9;7(39):5947-5955.  (SCI).
28.Lin YT, Chen ST, Chang JC, Teoh RJ, Liu CS, & Wang GJ.  Green extraction of healthy and
     additive free mitochondria with a conventional centrifuge. Lab on a Chip, 19(22), 3862-3869.
29.Liu SW, Chang JC, Chuang SF, Liu KH, Cheng WL, Chang HJ, Chang HS, Lin TT, Hsieh CL, Lin WY
    , Hsieh M, Kuo SJ, Liu CS.Far-infrared Radiation Improves Motor Dysfunction and Neuropathology
    in Spinocerebellar Ataxia Type 3 Mice.Cerebellum. 2019 Feb;18(1):22-32. 
30.Chuang CS, Chang JC, Soong BW, Chuang SF, Lin TT, Cheng WL, Orrd HT, Liu CS .
     Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse
     model of spinocerebellar ataxia type 1. Kaohsiung J Med Sci. 2019 Nov;35(11):679-685. Epub
     2019 Jul 4.(SCI).本人為共同第一作者
31.Wu HC, Chen ST, Chang JC, Hsu TY, Cheng, CC, Chang HS, ... & Liang ZC. Radical Scavenging and
     Antiproliferative Effects of Cordycepin-Rich Ethanol Extract from Brown Rice−Cultivated
     Cordyceps militaris (Ascomycetes) Mycelium on Breast Cancer Cell Lines.Int J Med Mushrooms.
    2019;21(7):657-669. (SCI). MOST 106-2314-B-317-007. 本人為通訊作者.
32.Chang JC, Chang HS, Wu YC, Cheng WL, Lin TT, Chang HJ, Chen ST, Liu CS.Antitumor Actions of
     Intratumoral Delivery of Membrane-Fused Mitochondria in a Mouse Model of Triple-Negative
     Breast Cancers.Onco Targets Ther. 2020 Jun 9;13:5241-5255.eCollection 2020.
33.Wu HC, Fan X, Hu CH, Chao YC, Liu CS, Chang JC*, Sen Y. Comparison of mitochondrial
     transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for
     hair aging in naturally aging mice. Biomedicine & Pharmacotherapy, 2020 Oct;130:110520. 
     本人為通訊作者.
34.Wu SL, Liu, KH, Cheng, WL, Su SL, Lin, YS, Lin TS, Cheng YS, Chang JC, W YL& Liu CS.Growth
     hormone rescue cerebellar degeneration in SCA3 transgenic mice. Biochem Biophys Res
     Commun .2020 Aug 20;529(2):467-473.  Epub 2020 Jul 2.
35. Hung YC, Huang KL, Chen PL, Li JL, Lu SH, Chang JC, Lin HY, Lo WC, Huang SY, Lee TT, Lin TY, Imai
      Y,Hattori N, Liu CS, Tsai SY, Chen CH, Lin CH, Chan CC.UQCRC1 engages cytochrome c for
      neuronal apoptotic cell death.Cell Rep. 2021 Sep 21;36(12):109729. 
36.Chang JC, Chao YC, Chang HS, Wu YL, Chang HJ, Lin YS, Cheng WL, Lin TT, Liu CS.  Intranasal
    delivery  of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-
    hydroxydopamine. Sci Rep. 2021 May 19;11(1):10597.MOST 106-2314-B-371-007. 本人為第一作
    者、通訊作者
37.Lin YT, Lin YS, Cheng WL, Chang JC, Chao YC, Liu CS, Wei AC. (2021, Jul). Transcriptomic and
     Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic
     Mice. Int J Mol Sci. 2021 Jul 26;22(15):7974. 
38.Chang JC, Chen L, Chang CR. Editorial: Mitochondrial therapy in neurological diseases.
    Front Mol Neurosci. 2022 Aug 1;15:988792.
39.Lin YS, Cheng WL, Chang JC, Lin TT, Chao YC, Liu CS. IGF-1 as a Potential Therapy for
     Spinocerebellar Ataxia Type 3. Biomedicines. 2022 Feb 21;10(2):505.
40.Chang JC, Chang HS, Yeh CY, Chang HJ, Cheng WL, Lin TT, Liu CS, Chen ST.  Regulation of
    mitochondrial fusion and mitophagy by intra-tumoral delivery of membrane-fused mitochondria
    or Midiv-1 enhances sensitivity to doxorubicin in triple-negative breast cancer. Biomed
    Pharmacother 2022 Sep;153:113484. Epub 2022 Aug 2. 本人為第一作者、通訊作者
41.Wu YL, Chen SC, Chang JC, Lin WY, Chen CC, Li CC, Hsieh M, Chen HW, Chang TY, Liu CS, Liu KL.
     The protective effect of erinacine A-enriched Hericium erinaceus mycelium ethanol extract on
     oxidative Stress-Induced neurotoxicity in cell and Drosophila models of spinocerebellar ataxia
     type 3.Free Radic Biol Med. 2023 Feb 1;195:1-12. Epub 2022 Dec 20.
42.Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS. In Vitro Efficacy and Molecular Mechanism
     of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type3. Antioxidants
     (Basel).2022 Jul 18;11(7):1389本人為共同第一作者
43.Wu YL, Chang JC, Sun HL, Cheng WL, Yen YP, Lin YS, Chao YC, Liu KH, Huang CS, Liu KL, Liu CS.
    Coenzyme Q10 Supplementation Increases Removal of the ATXN3 Polyglutamine Repeat,
    Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar
    Ataxia Type 3.Nutrients. 2022 Aug 31;14(17):3593.

◆ 論文著作(Poster論文)
1.[Poster] The effect of static magnetic field on the osteogenic differentiation of 
    rat dental pulp cells. -8th Annual Meeting of Tissue Engineering Society
    International， 2005， Shanghai， P.R.China.
2. [Oral presentation] The delivery of peptide-conjugated CdSe/ZnS quantum
    dots rescue the differentiation of human adipose-derived stem cells.- Stem
    Cells in Tissue Engineering-Isolation， Culture， Characterisation and
    Applications， ESF-EMBO Symposium， 2006， Sant Feliu de Guixols， Spain.
3.[Poster] Evaluation of a novel RGD-chimeric protein on chondrogenesis of rat
    adipose-derived adult stem cells embedded in alginate beads.- 8th World
   Biomaterials Congress， 2008， Netherlands， Amsterdam.
4.[Poster] Peptide-mediated mitochondrial transfer can rescue mitochondrial
    respiratory functions in cybrids harboring MERRF A8344G mutation， 2010，
    The 7th Conference of the Asian Society for Mitochondrial Research and
    Medicine(ASMRM) and The 10th Conference of Japanese Society of
    Mitochondrial Research and Medicine(J-mit)， 2010， Fukuoka， Japan.
5.[Poster] Evaluation of mitochondrial therapy via peptide-mediated
    mitochondrial transfer on human cells harboring MERRF A8344G mutation.
    2010. The Asia-Pacific Symposium on Mitochondrial Medicine and Genetic
    Diagnosis， Taipei.
6.[Poster] CYTOSKELETON ORGANIZATION AND MATRIX METALLOPROTEINASE
   EXPRESSION IN RESCUED MERRF SKIN FIBROBLASTS VIA PEPTIDE-MEDIATED
   MITOCHONDRIAL DELIVERY， 2011， The 5th SFRR-Asia， 8th Conference of
   the Asian Society for Mitochondrial Research and Medicine(ASMRM) and The
   11th Conference of Japanese Society of Mitochondrial Research and Medicine
   (J-mit)， 2011， Kagoshima， Japan.
7.Jui-Chih Chang, Fredrik Hoel, Yu-Shan Cheng, Ko-Hung Liu, August Hoel, Karl Johan Tronstad,
   Chin-San Liu, (2017, Sep). Far-infrared radiation protects viability in a cell model of Spinocerebellar
   Ataxia by improving mitochondrial function and facilitating polyQ protein degradation. The 8th
   Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia) & The 14th Conference of
   the Asian Society of Mitochondrial Research and Medicine (ASMRM): The Cross talk between Free
   Radicals and Mitochondria in Health and Disease, Xi’an, China . 本人為第一作者、通訊作者.
8. Sung-Tzu Chen, Jui-Chih Chang, Chin-San Liu, Chin-San Liu, Gou-Jen Wang (2018, Dec). A Novel
    Centrifugal Device for Mass-Production of Healthy Mitochondria. 2018 IEEE 12th International
    Conference on Nano/Molecular Medicine and Engineering (NANOMED), Waikiki Beach, HI, USA .
9.Jui-Chih Chang, Huei-Shin Chang, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ju Chang, Shou-Jen Kuo,
   Shou-Tung Chen, Chin-San Liu (2019, Nov). Mitochondrial transplantation reduces breast tumor
   growth in an advanced severe immunodeficiency mouse. 6th Conference of the ASMRM jointed
   with the 19th Conference of the J-mit: Explore the Mito-World!, Fukuoka, Japan. 本人為第一作者
  、通訊作者.
10.Jui-Chih Chang, Yi-Chun Chao, Chin-San Liu (2019, Dec). Intranasal delivery of mitochondria in
    therapeutic effect of 6-hydroxydopamine-lesioned rat models of Parkinson's disease . 15th
    Conference of the Asian Society of Mitochondrial Research and Medicine: MIRACLE,
    Mitochondrial Research Advancing Clinical Evolution, Park Hyatt Busan, Korea.
    MOST 107-2320-B-371-001-MY2.本人為第一作者、通訊作者.
11.Jui-Chih Chang*,Yi-Chun Chao,Wen-Ling Cheng,Ta-Tsung Lin, Chin-San Liu*(2020, Sep).
     Mitochondrial transplantation via nose?to?brain delivery for treatment of Parkinson’s diseases
     in rats. Taiwan Annual meeting of Society for Neuroscience, TSFN2020 congress, Taipei, Taiwan.
     MOST 107-2320-B-001-MY2.本人為第一作者、通訊作者.本人為通訊作者.
12.Jui-Chih Chang*, Han-Chiang Wu, Yi-Chun Chao and Chin-San Liu (2020, Nov). Comparison of
     mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich
     plasma therapy for hair aging in naturally aging mice. 2020 Annual Meeting of Taiwan Society for
     Mitochondrial Research, Hualien,Taiwan.本人為第一作者、通訊作者.