原力醫學院

張瑞芝

◆ 基本資料
   姓名:張瑞芝 Jui-Chih Chang
   地址: 500 彰化市旭光路235號 彰化基督教醫院 教學大樓7樓
   電話: +886-4-7238595 轉 4751或4752、4735
   Email : 145520@cch.org.tw

◆ 現任
   彰化基督教醫院原力醫學院執行長 2018/07~迄今
   彰化基督教醫院血管暨基因體研究中心研究員 2009/11~迄今
   彰化基督教醫院共同研究室 主任 2012/07~迄今 

◆ 學歷
   國立中興大學 生命科學院 博士 2004/07~2009/10
   私立中山醫學院 營養科學研究所 碩士 2000/07~2002/07
   私立靜宜大學 食品營養系 學士 1996/07~2000/07

◆ 經歷
  彰化基督教醫院血管暨基因體研究中心副主任 2012/07~2018/06
  彰化基督教醫院再生醫學研究室主持人 2011/08~2012/07
  彰化基督教醫院粒線體醫學研究室主持人 2009/11~2011/07
  日本京都大學短期進修 2009/06~2009/09
  中興大學組織工程與幹細胞中心 雷射聚共軛焦顯微鏡操作員 2005/10~2009/10
  廣三豐富牙醫診所 生物研究室 助理研究員 2002/09~2004/03

◆ 專科學會
  台灣粒線體醫學暨研究學會會員 、台灣幹細胞學會會員

◆ 專長
  粒線體醫學、神經退化疾病、粒線體移植、細胞生物 

◆ 專利
  1.Method and Application of Peptide -mediated Mitochondrial Delivery System
     (美國專利USUS20140178993A1)
  2. 胜?粒線體移植系統 台灣專利100120809號 張瑞芝/劉青山               2013/5/24   


◆ 論文著作 (期刊論文)
1.Chang JC, Su HL and Hsu SH. The use of peptide-delivery to protect human     adipose-derived adult stem  cells from damage caused by the internalization of
 quantum dots. Biomaterials.2008;29:925-36

2.Chang JC, Hsu Sh and Su HL.The regulation of the gap junction of human
   mesenchymal stem cells through the internalization of quantum dots.
   Biomaterials. 2009;30:1937-46. 

3.Chang JC, Hsu SH and Chen DC.The promotion of chondrogenesis in adipose-
   derived adult stem cells by an RGD-chimeric protein in 3D alginate culture.
   Biomaterials. 2009;30:6265-75.

4.Hsu SH and Chang JC. Static magnetic field promoted the mineralization of rat
   dental pulp cells. Cytotechnology, 2010; 62(2):143-55.

5.Chang JC, Shou-Jen Kou, Wei-Ting Lin and Chin-San Liu. The regulatory role of
   mitochondria in oxidative  stress and atherosclerosis. World of Journal
   cardiology, 2010.

6.Chang JC, Lee PC, Lin YC, Lee KW and Hsu S*.Primary Adipose-Derived Stem
   Cells Enriched by Growth  Factor Treatment Improves Cell Adaptability toward
   Cardiovascular Differentiation in a Rodent Model of  Acute Myocardial
   Infarction.J Stem Cells. 2011;6(1):21-37.
7.Sua SL,Wang WF,Wu SL, Chang JC, Huang CS et al. FGF21 in ataxia patients
   with spinocerebellar  atrophy and mitochondrial disease. Clinica Chimica Acta,
   2012;414:225-7.
8.Chang JC, Liu KH,Li YC,Kou SJ,Wei YH,Chuang CS,Hsieh M,Liu CS.Functional
   recovery of human cells harbouring the mitochondrial DNA mutation MERRF
   A8344G via peptide-mediated mitochondrial delivery. Neurosignals. 2013;21(3-
   4):160-73.
9.Chang JC, Liu KH, Chuang CS, Su HL, Wei YH, Kuo SJ, Liu CS. Treatment of
   human cells derived from myoclonic epilepsy and ragged red fibre (MERRF)
   disease by peptide-mediated mitochondrial delivery. Cytotherapy. 2013. 21(3-
   4):160-73.
10.Chang JC, Fujita S, Tonami H, Kato K, Iwata H, Hsu SH.Cell orientation and
     regulation of cell–cell  communication in human mesenchymal stem cells on
     different patterns of electrospun fibers. Biomed. Mater.2013,Oct;8(5):055002.
11.Chang JC, Liu KH, Chuang CS, Wu SL, Kuo SJ, Liu CS. Transplantation of Pep-
     1-labeled mitochondria protection against a 6-OHDA-induced neurotoxicity in
      rats. The Changhua Journal of Medicine, 2013,11:8-17.
12.Liu CS, Chang JC, Kuo SJ, Liu KH, Lin TT, Cheng WL, Chuang SF. Delivering
     healthy mitochondria for the  therapy of mitochondrial diseases and
     beyond.Int J Biochem Cell Biol. 2014 Aug;53:141-6. Epub 2014 May 16.
13.Chang JC, Wu SL, Hoel F, Cheng YS, Liu KH, Hsieh M, Hoel A, Tronstad KJ,
     Yan KC, Hsieh CL, Lin WY, Kuo SJ, Su SL, Liu CS. Far-infrared radiation
     protects viability in a cell model of Spinocerebellar Ataxia by  preventing polyQ
     protein accumulation and improving mitochondrial function. Sci Rep. 2016 Jul
      29;6:30436.
14.Huang PJ, Kuo CC,Lee HC, Shen CI,Cheng FC,Wu SF, Chang JC, Pan HC,
     Lin SZ, Liu CS and Su HL. Transferring xenogenic mitochondria provides
     neural protection against ischemic stress in ischemic rat  brains. Cell
     transplantation, 2016, 25(5), 913-927.
15.Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH,
     Kuo SJ and Liu CS*. Allo-/xenogeneic transplantation of peptide-labelled
     mitochondria in Parkinson’s disease: restoration of mitochondria functions and
     attenuation of 6-OHDA-induced neurotoxicity. Translational Research. 2016,
     Vol.4:115-127.
16.Chuang CS, Chang JC, Cheng FC, Liu KH, Su HL, Liu CS. Modulation of
     mitochondrial dynamics by treadmill training to improve gait and
     mitochondrial deficiency in a rat model of Parkinson's disease. Life Sci. 2017
     Dec 15;191:236-244. Epub 2017 Oct 3.
17.Hsiao CC, Chang JC, Tsao LY, Yang RC, Chen HN, Lee CH, Lin CY, Tsai YG.
    Correlates of Elevated  Interleukin-6 and 8-Hydroxy-2'-Deoxyguanosine Levels
    in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop
    Bronchopulmonary Dysplasia. Pediatr Neonatol. 2017 Feb;58(1):63-69. Epub
    2016 May 30.
18.Wu YL, Chang JC, Lin WY,Li CC,Hsieh Ml, Chen HW,Wang TS,Liu CS,Liu KL.
    Treatment with Caffeic  Acid and Resveratrol Alleviates Oxidative Stress
    Induced Neurotoxicity in Cell and Drosophila Models of  Spinocerebellar Ataxia
    Type3. Sci Rep. 2017 Sep 14;7(1):11641.
19.Chang JC, Hoel F, Liu KH, Wei YH, Cheng FC, Kuo SJ, Tronstad KJ, Liu CS.
    Peptide-mediated delivery of donor mitochondria improves mitochondrial
    function and cell viability in human cybrid cells with the MELAS A3243G
    mutation. Sci Rep. 2017 Sep 6;7(1):10710.
20.Chang JC,Yeh CY,Chang TL,Liu KH,Soong BW,Hsieh ML,Chang T,Liu CS.In
    vivo and In vitro Studies of Mitochondrial Transplantation for the Treatment of
    Spinocerebellar Ataxia Type 3. The Changhua Journal of Medicine, 2017, 15(4),
    176-193.

21.Wu YL,Chang JC,Lin WY,Li CC,Hsieh ML, Chen HW, Wang TS, Wu WT, Liu CS,
     Liu KL.Caffeic  acid and resveratrol ameliorate cellular damage in cell and
     Drosophila models of spinocerebellar ataxia type 3 through upregulation of
     Nrf2 pathway. Free Radic Biol Med.2018 Feb 1;115:309-317.Epub 2017
     Dec 13.
22.Liu SW, Chang JC,Chuang SF,Liu KH,Cheng WL,Chang HJ,Chang HS,Lin TT,
     Hsieh CL, Lin WY, Hsieh M,Kuo SJ,Liu CS. Far-infrared Radiation Improves
     Motor Dysfunction and Neuropathology in Spinocerebellar Ataxia Type 3
     Mice.Cerebellum 2018 May 3.[Epub ahead of print]
23.Chang JC ,Chang HS, Liu CS, Chen ST. Mitochondrial organelle delivery in
     therapy of breast  cancer in  vitro. 1st International Mitochondria Meeting for
      Young Scientists, 2018 Japan, Kagoshima.
24.Yamano, K., & Lazarou, M. (2018). YoungMito 2018: Report on the 1st
     International Mitochondria Meeting for Young Scientists. Genes to Cells,
     23(10), 822-827. Chang JC ,Chang HS., Liu CS, Chen ST. Mitochondrial
     organelle delivery in therapy of breast cancer in vitro. 1st  International 
      Mitochondria Meeting for Young Scientists, 2018 Japan, Kagoshima.

25.Hsiao YH, Li CW, Chang JC, Chen ST, Liu CS & Wang GJ. Chemical-Free
    Extraction of Functional Mitochondria Using a Microfluidic Device. Inventions
    2018, 3(4), 68.

◆ 論文著作(Poster論文)
1.[Poster] The effect of static magnetic field on the osteogenic differentiation of 
    rat dental pulp cells. -8th Annual Meeting of Tissue Engineering Society
    International, 2005, Shanghai, P.R.China.

2. [Oral presentation] The delivery of peptide-conjugated CdSe/ZnS quantum
    dots rescue the differentiation of human adipose-derived stem cells.- Stem
    Cells in Tissue Engineering-Isolation, Culture, Characterisation and
    Applications, ESF-EMBO Symposium, 2006, Sant Feliu de Guixols, Spain.
3.[Poster] Evaluation of a novel RGD-chimeric protein on chondrogenesis of rat
    adipose-derived adult stem cells embedded in alginate beads.- 8th World
   Biomaterials Congress, 2008, Netherlands, Amsterdam.

4.[Poster] Peptide-mediated mitochondrial transfer can rescue mitochondrial
    respiratory functions in cybrids harboring MERRF A8344G mutation, 2010,
    The 7th Conference of the Asian Society for Mitochondrial Research and
    Medicine(ASMRM) and The 10th Conference of Japanese Society of
    Mitochondrial Research and Medicine(J-mit), 2010, Fukuoka, Japan.

5.[Poster] Evaluation of mitochondrial therapy via peptide-mediated
    mitochondrial transfer on human cells harboring MERRF A8344G mutation.
    2010. The Asia-Pacific Symposium on Mitochondrial Medicine and Genetic
    Diagnosis, Taipei.

6.[Poster] CYTOSKELETON ORGANIZATION AND MATRIX METALLOPROTEINASE
   EXPRESSION IN RESCUED MERRF SKIN FIBROBLASTS VIA PEPTIDE-MEDIATED
   MITOCHONDRIAL DELIVERY, 2011, The 5th SFRR-Asia, 8th Conference of
   the Asian Society for Mitochondrial Research and Medicine(ASMRM) and The
   11th Conference of Japanese Society of Mitochondrial Research and Medicine
   (J-mit), 2011, Kagoshima, Japan.

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