基本資料
蘇矢立 Shih-Li Su
電話： +886-4-7238595 轉 3239
Email ： 89933@cch.org.tw
◆ 現任
彰化基督教醫院血管醫學及糖尿病研究中心 主任 2005/07-迄今
彰化基督教醫院內分泌暨新陳代謝科 主治醫師 2000/07-迄今
中山醫學大學醫學系兼任講師 2005/08-迄今
◆ 學歷
中山醫學大學 醫學研究所 博士2005/09-2014/01
中山醫學大學 醫學研究所 醫學碩士 2003/09-2005/06
中國醫藥學院 中醫學系 醫學士 1980/9-1986/06
◆ 經歷
彰化基督教醫院人體試驗委員會行政中心 主任 2011/08-2023/06
彰化基督教醫院血管醫學防治中心協同主任2010/07-2021/05
彰化基督教醫院教學部 主任 2014/07-2018/06
彰化基督教醫院共同研究室 負責人 2013/07-2014/06
彰化基督教醫院受試者保護辦公室 主任 2011/08-2012/07
彰化基督教醫院糖尿病健康e院研究部 主任 2011/02-2012/07
彰化基督教醫院 骨鬆暨減重中心 主任 2001/05-2011/02
中央健保局台中門診中心約聘醫師
沙鹿光田綜合醫院 內分泌暨新陳代謝科 主治醫師 1996-2000
台北三軍總院 內科部 內分泌暨新陳代謝科 進修醫師 1994/07-1996/06
沙鹿光田綜合醫院內科主治醫師 1992-1994
沙鹿光田綜合醫院內科總醫師 1991-1992
沙鹿光田綜合醫院內科住院醫師 1988-1991
◆ 專長
內分泌及新陳代謝、糖尿病、血脂相關、骨質疏鬆、粒線體等相關研究
◆歷年計畫:
1.高血脂病患服用降血脂藥物 Statin 前後其低密度脂蛋白氧化與抗體生成之相關研究(97-CCH-ICO-20-2)
彰基院內整合型計畫子計畫主持人97.03-99.12
2.糖尿病與骨質鬆疏病患之低密度膽固醇受體蛋白與氧化低密度膽固醇相關性(99-CCH-IRP-18)彰基院內個
人型計畫主持人99.03-100.12
3.鎂離子活性與台灣人代謝症候群相關性之研究（100-CCH-IRP–23)彰基院內個人型計畫主持人100.01
-101.12
4.T細胞調整路徑 Th1 及 Th2 的生物指標在骨質疏鬆症的相關研究（101-CCH-IRP-38）彰基院內個人型計
畫主持人101.3-103.2
5.Cyclophilin A 在人類心血管疾病預防之應用（101-CCH-ICO-001-2）彰基院內整合型計畫子計畫主持人
101.09-104.08
6.高果糖飲食對小鼠心臟粒腺體心脂磷蛋白之影響（103-CCH-IRP-014）彰基院內個人型計畫主持人
103.03-105.02
7.在第二型糖尿病造成腎功能病變時粒腺體與Cyclophilins 之相關性（MOST 103-2314-B-371 -010）科
技部專題研究計畫主持人103.8-104.7
8.高血糖誘發腎臟間質細胞途徑中神經醯胺與環孢素受體A 及環孢素受體D 的相聯（104-CCH-IRP-015）
彰基個人型計畫主持人104.3-106.2
9.第二型糖尿病造成腎功能病變時粒腺體與環孢素受體A 之相關性（104-CCH-MST-001）彰基專案型研究
計畫持人104.3-106.2
10.不同葡萄糖刺激下胰腺B,腎HK2 和Mes 細胞的miRNA 及其相關蛋白的表達（105-CCH-IRP-014）彰基
個人型計畫主持人105.3-107.2
11.糖尿病患者血漿神經醯胺是否會是葡萄糖誘發粒線體功能退化的重要因素（106-CCH-IRP-095）彰基個
人型計畫主持人106.12-107.12
12.神經醯胺干預粒線體生成於人類腎臟間質細胞(108-CCH-IRP-114)彰基個人型計畫主持人108.04
-109.03
13.在肥胖糖尿病患者出現的粒線體障礙可能與神經醯胺1-磷酸鞘氨醇不平衡(109-CCH-IRP-033)彰基個人
型計畫主持人108.07-110.06
14.神經醯胺對於肥胖第二型糖尿病患者造成粒線體受損之影響(110-CCH-IRP-099)彰基個人
型計畫主持人110.05-112.07
15.包裹在脂質體中的輔? Q10 可有效治療高糖和超負荷脂肪誘導的粒線體損傷(111-CCH-IRP-076)彰基個
人型計畫主持人111.05-113.07
16.探討糖胖症患者血漿中 CoQ10與粒線體損傷相關性(112-CCH-IRP-085)彰基個人型計畫主持人112.05
-114.04
17.神經醯胺及CoQ10對糖胖症粒線體損傷之探討(112-CCH-IRP-157)112.12-113.11
◆ 論文著作
1. Wang SY,Hsu HR,Su SL*，Tu ST. Sheehan's syndrome presenting with early postpartum
congestive heart failure. J Chin Med Assoc. 2005 Aug;68(8):386-91.
2.蔡佩凌、蔡玉娟、*蘇矢立 (2007) Thiazolidinediones 之臨床效益與風險. Drug Safety Newsletter 2007
Sept. Vol.19：7-13.
3.Hwang JS,Chen JF,Yang TS,Wu DJ,Tsai KS,Ho C,Wu CH, Su SL,Wang CJ,Tu ST.The effects of
strontium ranelate in Asian women with postmenopausal osteoporosis. Calcif Tissue
Int.Nov;2008; 83(5):308-314.
4.Hsu SR,Lin SD, Tu ST,Liao PY,Su SL,Lin SL,Tseng YY,Huang PW. Metabolic control with insulin
pump therapy:preliminary experience. J Chin Med Assoc. 2008;Jul;71(7):353-356.
5.*蘇矢立、杜思德 (2008) 高血脂現代文明人的殺手. Endocrinology and Diabetology. 21(2):10-12.
6.Lin SD, Wang YM,Tu SD, Su SL,Wang HF. The appearance of red blood cell residue within insulin
cartridges.Endocrinology and Diabetology. 2008; 21(3):23-26.
7.Lin SD, Tu ST, Su SL, Lin SL,Tseng YY,Huang PW. The Attitude of Care Providers in-Preliminary
Report. Endocrinology and Diabetology. 2008; 21(4):55-61
8.蘇矢立、林淑滿、林世鐸、林素蘭、廖培湧、黎煥中(Bulletin 2008.12).利用網路或PDA手機照護系統對
第2型糖尿病自我血糖監測的初步報告.Tawanese Assoctiation of Diabetes Educators.18-22
9.廖培湧、蘇矢立、王舒儀、林素蘭、吳靜雯、陳巧雲. (Bulletin 2009.03).財團法人彰化基督教醫院糖尿病
優質促進機構介紹Tawanese Assoctiation of Diabetes Educators.30-33
10.劉兆坤、王川銘、陳美櫻、林世鐸、蘇矢立. (Bulletin 2009.06).有別以往的判別-升糖作用
(Glycemicimpact) Taiwanese Assoctiation of Diabetes Educators.7-11
11.何孟穎、劉兆坤、王川銘、蘇矢立. (Bulletin 2009.09).當糖尿病患者遇到油脂酸敗時應有的認知.
Taiwanese Assoctiation of Diabetes Educators.35-38
12.張立、劉兆坤、王川銘、蘇矢立(Bulletin 2009.09).砷和糖尿病的關係Taiwanese Assoctiation of
Diabetes Educators.39-43
13.Su SL (2009) Sodium-Glucose Transporter. Formosan Journal of endocrinology and metabolism
1(1):1-5.
14.王川銘、曾雅玉、黃倍紋、林素蘭、林世鐸、蘇矢立. (Bulletin 2009.12).透過及遠距管理來照護第1型糖
尿病孕婦之經驗.Taiwanese Assoctiation of Diabetes Educators.26-28.
15.Su SL, Jou S, Cheng W, Lin T, Li J, Huang C, Lee Y, Soong B, Liu CS*.Mitochondrial DNA damage
in spinal and bulbar muscular atrophy patients and carriers.Clin Chim Acta. 2010 May 2;411
(9-10):626-30.[Epub 2009 Dec 24.]
16.Liu CS,Lii CK,Chang LL,Kuo CL,Cheng WL,Su SL,Tsai CW,Chen HW. Atorvastatin increases blood
ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein
cholesterol in hypercholesterolemic patients .Nutr Res. 2010 Feb;30(2):118-24.
17.Chen JX, Su SL,Chang CH. Diabetes care decision support system. 2nd international conference
on industrial systems 2010; IIS: 323-326.
18.Chen JX, Su SL， Chen ZL. Sharing and integration of profession ontology by web service–An
example of diabetes care. 2nd international conference on industrial systems. 2010; 2:V2-136-140
19.王碧瑩、吳月珠、黃紫芬、廖文珊、蘇矢立. (Bulletin 2010.06)糖尿病患在遊樂園如何玩的盡興玩的安
心之使用須知.Taiwanese Assoctiation of Diabetes Educators：35-39
20.鄭智維、吳靜雯、陳巧雲、梁珮甄、蘇矢立. (Bulletin 2010.09)當糖尿病遇上災害時應如何自處.
Taiwanese Assoctiation of Diabetes Educators：22-24
21.葉汶沁、劉兆坤、王川銘、蘇矢立. (Bulletin 2010.09)面對天然災害糖尿病患飲食該如何調整.
Taiwanese Assoctiation of Diabetes Educators：25-27
22.鐘杏鸞、張立、陳巧雲、陳怡瑜、蘇矢立. (Bulletin 2010.09)膠原蛋白與糖尿病.Taiwanese
Assoctiation of Diabetes Educators：28-34
23.劉兆坤、蘇矢立. (Bulletin 2010.09)素食可延緩糖尿病的惡化.Taiwanese Assoctiation of Diabetes
Educators：35-36
24.王川銘、蘇矢立. (Bulletin 2010.09)吃素是好是壞.Taiwanese Assoctiation of Diabetes Educators：
37-38
25.葉汶沁、王碧瑩、王川銘、劉兆坤、蘇矢立. (Bulletin 2010.09)血糖與癌症.Taiwanese Assoctiation
of Diabetes Educators：39-42
26.施宜德、林益卿、蘇矢立. 亞臨床型甲狀腺低能症.家庭醫學與基礎醫療第25卷第7期254-259.
27.林美蓉、蔡玉娟、蘇矢立.糖化血紅素成為糖尿病診斷工具後衛教人員應有的認知(Bulletin 2010.12)
Taiwanese Assoctiation of Diabetes Educators：1-3
28.李晏慈、杜思德、蘇矢立、郭仁富.粒線體型糖尿病個案照護之經驗分享(Bulletin 2010.12)
Taiwanese Assoctiation of Diabetes Educators：29-31
29.蘇矢立、林素蘭、林淑滿、吳靜雯.談妊娠糖尿病的診斷(Bulletin 2011.03) Taiwanese Assoctiation
of Diabetes Educators：12-14
30.陳信宏、蘇矢立.減重手術是否成為治療第二型糖尿病的新選擇(Bulletin 2011.03) Taiwanese
Assoctiation of Diabetes Educators：25-28
31.林冠怡、林佩姿、蘇矢立.類固醇與糖尿病(Bulletin 2011.03) Taiwanese Assoctiation of Diabetes
Educators：32-34
32.Wang JS, Lin SD, Lee WJ, Su SL, Lee IT, Tu ST, Tseng YH, Lin SY, Sheu WH. Effects of acarbose
versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients
inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group
comparison.Clin Ther. 2011 Dec;33(12):1932-42. Epub 2011 Nov 10.
33.Lin SD,Wang JS,Hsu SR, Sheu WH, Tu ST, Lee IT,Su SL, Lin SY, Wang SY, Hsieh MC. The
beneficial effect of α-glucosidase inhibitor on glucose variability compared with sulfonylurea
in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary
data. J Diabetes Complications. 2011 Sep-Oct;25(5):332-8
34.Huang CH,Su SL, Hsieh MC, Cheng WL, Chang CC, Wu HL, Kuo CL, Lin TT, Liu CS. Depleted
Leukocyte Mitochondrial DNA Copy Number in Metabolic Syndrome. J Atheroscler Thromb.
2011;18(10):867-73.
35.蘇矢立、林美蓉、劉兆坤.聖露西亞醫療志工行腳心得(Bulletin 2011.09) Taiwanese Assoctiation of
Diabetes Educators：42-44
36. Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N,
Persson F, Desai AS,Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA; ALTITUDE
Investigators.N Engl J Med. 2012 Dec 6;367(23):2204-13. [Epub 2012 Nov 3.]
37.Yu SC, Kuo CL, Huang CS, Chang CS, Wu SL, Su SL, Liu CS. Endogenous granulocyte colony -
stimulating factor: a biomarker in acute ischemic stroke. Biomarkers. 2012 Jun;17(4):319-24.
[ Epub 2012 Mar 23.]
38. Su SL, Wang WF,Wu SL,Wu HM,Chang JC, Huang CS, Cheng WL, Soong BW, Lee YC, Li JY，
Kuo SJ, Chen M,Huang CN, Liu CS. FGF21 in ataxia patients with spinocerebellar atrophy and
mitochondrial disease. Clin Chim Acta. 2012 Sep 29;414C:225-227.(計畫 編號:NSC -2314 -B-
371 -003 -MY2 from the National Science Council and CCH 100 -IRP-109 from the Changhua
Christia. )
39.Chen YH, Yeh CW, Lo HC, Su SL, Hseu YC, Hsu LS. Generation of reactive oxygen species mediates
butein-induced apoptosis in neuroblastoma cells. Oncol Rep. 2012 Apr;27(4):1233-7.[Epub 2012
Jan 12.]
40.Chang CS, Su SL, Chang CC, Lee KW, Kuo CL, Huang CS, Tseng WM, Liu CS. Cyclophilin A:
A Novel Biomarker for Untreated Male Essential Hypertension. Biomarkers. 2013 Dec;18
(8):716-20. (計畫 編號: 97 -CCH -ICOICOICO-19 -2, 97 -CCH -ICOICOICO-21 -2 and 97 2
and 97 -CCH -ICOICOICO-20 -2)
41.Su SL, Kuo CL,Huang CS, Liu CS. Fibroblast Growth Factor 21 Predicts Type 2 Diabetes in
Taiwanese. The Changhua Journal of Medicine 2013;11(1):42-47. (計畫 編號:99 -CCH -IRP-
18 -92016 )
42.Su SL, Kuo CL, Liu CS. Diabetes and Mitochondria. The Changhua Journal of Medicine 2013;
11(1):1-7.
43.Chen YH,Lin WW,Liu CS, Hsu LS, Lin YM, and Su SL*. Caveolin-1 palliates renal oxidative
damage in hypercholesterolemic rabbits. The Changhua Journal of Medicine 2013; 11(1):18-
25.
44.Chen YH, Lin WW, Liu CS, Hsu LS, Lin YM, Su SL*. Caveolin-1 provides palliation for adverse
hepatic reactions in hypercholesterolaemic rabbits. PLoS One. 2014 Jan 24;9(1):e71862.
(corresponding author)
45. Chen PH, Tsai YT,Wang JS, Lin SD,Lee WJ, Su SL, Lee IT, Tu ST, Tseng YH,Sheu WH,Lin SY.
Post-meal β-cell function predicts the efficacy of glycemic control in patients with type 2
diabetes inadequately controlled by metformin monotherapy after addition of glibenclamide
or acarbose. Diabetol Metab Syndr.2014 May 31;6:68.
46.Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S,
Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB; LEADER
Steering Committee; LEADER Trial Investigators. Liraglutide and Cardiovascular Outcomes in
Type 2 Diabetes. N Engl J Med. 2016 Jul 28;375(4):311-22. [ Epub 2016 Jun 13.]
47.Chen YH, Lin WW, Liu CS, Hsu LS, Lin YM, Su SL*. Caveolin-1 Expression Ameliorates Nephrotic
Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia. PLoS One. 2016 Apr
28;11(4):e0154210. (corresponding author)
48.Hsieh YT, Kuo JF, Su SL, Chen JF, Chen HC, Hsieh MC.Subnormal Estimated Glomerular
Filtration Rate Strongly Predict Incident Cardiovascular Events in Type 2 Diabetic Chinese
Population With Normoalbuminuria.Medicine (Baltimore). 2016 Jan;95(2):e2200.
49.Chang JC, Wu SL, Hoel F, Cheng YS, Liu KH, Hsieh M, Hoel A, Tronstad KJ, Yan KC, Hsieh
CL, Lin WY, Kuo SJ, Su SL, Liu CS. Far-infrared radiation protects viability in a cell model of
Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving
mitochondrial function. Sci Rep. 2016 Jul 29;6:30436. (計畫 編號: NSC 103-2314-B-371
-005)
50.Wang JS, Lee IT, Lee WJ, Lin SD,Su SL, Tu ST, Tseng YH, Lin SY, Sheu WH.Diabetes Res Clin
Pract. 2016 Mar;113:108-15.
51.Ko PY, Lin SD, Tu ST, Hsieh MC, Su SL,Hsu SR, Chen YC5.High diabetes mellitus prevalence
with increasing trend among newly-diagnosed tuberculosis patients in an Asian population: A
nationwide population-based study.Prim Care Diabetes. 2016 Apr;10(2):148-55.
52.Lin SD, Su SL, Wang SY, Tu ST, Hsu SR. Using continuous glucose monitoring to assess
contributions of premeal and postmeal glucose levels in diabetic patients treated with
metformin alone. Diabetes Metab. 2016 Nov;42(5):336-341.[ Epub 2016 Apr 7.] IF=4.693, 24/133
53.Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman
B,Buse JB; LEADER Steering Committee and Investigators. Liraglutide and Renal Outcomes in
Type 2 Diabetes. N Engl J Med. 2017 Aug 31;377(9):839-848.
54.Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J,
Gustavson SM,Iqbal N, Maggioni AP, Marso SP, Öhman P, Pagidipati NJ, Poulter N,
Ramachandran A, Zinman B,Hernandez AF; EXSCEL Study Group. N Engl J Med. 2017 Sep
28;377(13):1228-1239.[ Epub 2017 Sep 14.]
55.Chen YH, Lin WW, Liu CS, Su SL. H2O2 induces caveolin?1 degradation and impaired
mitochondrial function in E11 podocytes. Mol Med Rep. 2017 Nov;16(5):7841-7847.
(corresponding author)
56. Lin HC, Su SL, Lu CY, Lin AH, Lin WC, Liu CS, Yang YC, Wang HM, Lii CK, Chen HW.
Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating
Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial
cells. Environ Toxicol. 2017 Mar;32(3):918-930.[Epub 2016 Jun 14.] (Co-first author)
57.Wang JS, Lee IT, Lee WJ, Lin SD, Su SL, Tu ST, Tseng YH, Lin SY, Sheu WH. Glycemic
excursions are positively associated with HbA1c reduction from baseline after treatment with
acarbose in patients with type 2 diabetes on metformin monotherapy. J Diabetes. 2017
Mar;9(3):248-255.
58.Lin HC, Su SL, Lin WC, Lin AH, Yang YC, Lii CK, Chen HW. Andrographolide inhibits hypoxia-
induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme
oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells. Environ Toxicol. 2018 Mar;33
(3):269-279. [Epub 2017 Nov 22.] (Co-first author)
59.Chang CS, Su SL, Kuo CL, Huang CS, Tseng WM, Lin SS, Liu CS. Cyclophilin A: A predictive
biomarker of carotid stenosis in cerebral ischemic stroke. Curr Neurovasc Res. 2018;15
(2):111-119.
60.Hsieh MC, Tsai WH, Jheng YP, Su SL, Wang SY, Lin CC, Chen YH, Chang WW. The beneficial
effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a
randomized, double-blinded, placebo-controlled trial. Sci Rep. 2018 Nov 14;8(1):16791.
61.Chiu PF*, Su SL*, Tsai CC, Wu CL, Kuo CL, Kor CT, Chang CC, Liu CS. Cyclophilin A and CD147
associate with progression of diabetic nephropathy.Free Radic Res. 2018 Dec 20:1-8. [Epub
ahead of print] [Epub 2018 Dec 20.] (Co-first author)
62.Su SL, Kuo CL,Su CW,Huang CS,Tseng WM,Hsieh ML*,†, Liu CS*,†.Secreted Cyclophilin A
Is an Inflammatory Marker in Patients With Diabetic Nephropathy. The Changhua Journal of
Medicine 2018;16:143-151(Co-first author)
63.Kuo CL, Yang JT, Tseng WM, Huang CS, Yang TC, Liu CS*；Su SL* .A Novel Biomarker CD147
Predict Mortality in Diabetes Patients After a 10-Year Follow-Up. The Changhua Journal of
Medicine 2019;17:1-7. (corresponding author)
64.Lee IT, Hsu CC, Sheu WH, Su SL, Wu YL, Lin SY. Pay-for-performance for shared care of diabetes in
Taiwan. J Formos Med Assoc. 2019 Aug 27. pii: S0929-6646(19)30350-X.
65.Lin CH, Kuo SC, Hsieh MC, Ho SY, Su IJ, Lin SH, Chi CY, Su SL, Liao CY, Chen YC, Hsu SR, Huang YC,
Tseng FC, Wang SY, Dou HY, Lin SD, Lin JS, Tu ST, Yeh YP; Changhua Research Alliance for
Tuberculosis Elimination. Effect of diabetes mellitus on risk of latent TB infection in a high TB
incidence area: a community-based study in Taiwan. BMJ Open. 2019 Oct 28; 9(10):e029948.
66.Hsieh MC, Tsai WH, Jheng YP, Su SL, Wang SY, Lin CC, Chen YH, Chang WW. Author Correction:
The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes
mellitus:a randomized, double-blinded,placebo-controlled trial. Sci Rep . 2020
Feb 26;10(1):3872.
67.Wang JS, Lee IT, Lee WJ, Lin SD, Su SL, Tu ST, Lin SY, Sheu WH.The dawn phenomenon in type 2
diabetes: its association with glucose excursions and changes after oral glucose-lowering
drugs.Ther Adv Chronic Dis. 2021 Aug 10;12:20406223211033674.
68.Cheng YS；Kuo CL；Huang CS；Liu CS；Su SL.Ceramide and Fingolimod Impact Mitochondrial
Apoptosis in Human Renal Mesangial Cells.The Changhua Journal of Medicine 2022;20:35-44
69.Hu TH, Luh DL, Tsao YY, Lin TY, Chang CJ, Su WW, Yang CC, Yang CJ, Chen HP, Liao PY, Su SL, Chen
LS,Hsiu-Hsi Chen T, Yeh YP; Changhua Hepatitis C Elimination Task Force.Using the Diabetes
Care System for a County-Wide Hepatitis C Elimination: An Integrated Community-Based Shared
Care Model in Taiwan.Am J Gastroenterol. 2024 Jan 22. Online ahead of print.