原力醫學院

劉青山

PERSONAL INFORMATION

Name: Chin-San Liu, M.D., Ph.D.

 

POSITION TITLE 

2008/1~

Vice-Superintendent, Changhua Christian Hospital, Changhua, Taiwan       

2000/7~

Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan

2000/7~

Chief, Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan 

2017/7~

Director, Institute of ATP, Changhua Christian Hospital, Changhua, Taiwan

1999/1~

Adjunct Professor of Neurology, China Medical University, Taichung, Taiwan

2009/8~

Adjunct Professor of Neurology, Chung Shan Medical University, Taichung, Taiwan

2016/1~

President of Taiwan Society for Mitochondrial Research and Medicine

2016/9~

Vice president, Society for Neurological Rare Disorders

2019/1~201912/31

Adjunct research fellow, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.

 

◆EDUCATION

1992/9~1998/1

Ph.D   National Yang-Ming University Institute of Clinical Medicine, Taipei, Taiwan

1979/7~1986/6

M.D   China Medical University, Taichung, Taiwan

2004/1~2004/6

Visiting-scholar, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan

2010/4

Visiting-scholar, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, US

2016/4

Visiting-scholar, Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Research, University College London, London, United Kingdom

 

◆ACADEMIC APPOINTMENT

2005/6~2007/4

Convener of Neurogenetic, Taiwan Neurology Society

2012/5~2013/9

President, Australasian College of Medical Science and Research-Taiwan Branch

2013/1~2016/1

Executive Director of Taiwan Society for Mitochondrial Research and Medicine

2016/11~2018/11

President, Asia Society of Mitochondrial Research and Medicine

 

◆HOSPITAL APPOINTMENTS

1994/7~1999/7

Chief, Department of Neurology, Kuang Tien General Hospital

2000/7~

Attending Physician, Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan

2006/4~2007/1

Attending Physician, Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan

2008/5~2009/7

Chief, Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan

2010/1~2012/6

Chief, Administration Center of Research and Education, Changhua Christian Hospital, Changhua, Taiwan 

2014/7~2015/6

Superintendent, College of Research and Education, Changhua Christian Hospital, Changhua, Taiwan 

 

◆PROFESSIONAL FIELD

Neurogenetic disorder, Cardiovascular disease

 

PUBLICATION (*CORRESPONDING AUTHOR)2000-2018

  1. Liu CS, Lii CK, Ou CC, Tsai CH, Wei YH, Chen H.W. (2000) Autoantibody against oxidized low-density lipoproteins may be enhanced by cigarette smoking. Chem-Biol Interact 127: 125-137.
  2. Hwang CT, Huang LL, Liu CS. (2000) Dietary habits and behavioral characteristics of gout patients in an aboriginal village, Taugyue of han county in Taiwan. Nutr Sci J 25: 62-72.
  3. Liu CS, Lim PS, Kao SH, Wei Y.H. (2001) Biomarkers of DNA damage in patients with end-stage renal disease: mitochondrial DNA mutation in hair follicles. Nephrol Dialy Transplan 16: 561-565.
  4. Wu HM., Liu CS*, Tsai JJ, Ko LY, Wei Y.H. (2002) Antioxidant and anticonvulsant effect in Chinese herbal mixture (TW970) American Journal of Chinese Medicine 30(2): 339-34
  5. Chu CC, Huang CC, Kuo HC, Liu CS. and Tsai CS. (2002) Sensory neuropathy in X-recessive bulbospinal neuronopathy. J. Formos. Med. Assoc. 101:214-218.
  6. Liu CS,* and Tsai, C.S. (2002) Enhanced Lipid Peroxidation in Epileptics with Null Genotype of Glutathione S-transferase M1 and Intractable Seizure. Jpn. J. Pharmacol. 90: 291-294.
  7. Liu CS, Chen HW, Lii CK, Tsai CS, Kuo CL, Wei YH. (2002) Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers. Environ. Mol. Mutagen. 40:168-174.
  8. Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M. (2003) Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3.FEBS Lett. 546:307-314.
  9. Tsai HF, Liu CS, Chen GD, Lin ML, Li C, Chen YY, Wang BT. and Hsieh M. (2003) Prenatal Diagnosis of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3 in Taiwan: Early Detection of Expanded Ataxin-3. Journal of Clinical Laboratory Analysis 17: 195-200.
  10. Hsiao KM, Chen SS, Li SY , Chiang SY, Lin HM, Pan H, Chen CC, Kuo HC, Jou SB, Su CC, Ro LS, Liu CS, Lo MC, Chen CM, Lin CC. (2003) Epidemiological and Genetic Studies of Myotonic Dystrophy Type 1 in Taiwan. Neuroepidemiology 22: 283-289.
  11. Liu CS, Tsai CS, Kuo CL, Chen HW, Lii CK, Ma YS, Wei YH. (2003)Oxidative Stress-related Alteration of the Copy Number of Mitochondrial DNA in Human Leukocytes. Free Radical Research 37: 1307-1317.
  12. Tsai HF, Liu CS, Leu TM, Wen FC, Lin SJ, Liu CC, Yang DK, Li C, Hsieh M (2003) Analysis of Trinucleotide Repeats IN Different SCA Loci in Spinocerebellar Ataxia Patients and in Normal Population of Taiwan. Acta Neurol Scand109: 355-360.
  13. .Liu CS, Chiang TH, Kuo CL, Lii CK, Ou CC, Wei Y.H, Chen HW. (2004) α-  tocopherol is important to inhibit low-density lipoprotein oxidation in smokers. Nutrition research 24: 361-371.
  14.  Liu CS, Chiang, H.C, Chen HW. (2004) Methylenetetrahydrofolate Reductase Polymorphism Determines the Plasma Homocysteine-Lowering Effect of High-Dose Folic Acid Supplementation in Patients with Cardiovascular Disease. Nutrition, 20:974-978.
  15. Liu CS, Chiang TH, Kuo CL, Ou CC, Lii CK, I SH, Wei YH, Chen HW. (2005)Contribution Of Plasma Folic Acid And Homocysteine Levels To The Mean Carotid Intima Media Thickness In Smokers. Nutrition Research 25; 835–845.
  16. Liu CS*, Hsieh M, Chen YY, Lo MC. (2005) Machado-Joseph Shoe. Movement Disorders 20(1):66-68.
  17. Liu CS, Kuo CL, Cheng WL, Huang CS, Lee CF, Wei YH. (2005) Alteration of the Copy Number of Mitochondrial DNA in Leukocytes of Patients with Hyperlipidemia. Ann NY Acad Sci. 1042: 70–75.
  18. Liu CS, Cheng WL, Chen YY, Tsai CS, Ma YS, Cheng YP., Wei YH. (2005) High Prevalence of the COII/tRNALys Intergenic 9-bp Deletion in Mitochondrial DNA of Taiwanese Patients with MELAS or MERRF Syndrome, Ann. N.Y. Acad. Sci. 1042: 82-87.
  19. Liu CS, Hsu HM, Cheng WL, Hsieh M. (2005) Clinical and molecular events in patients with Machado-Joseph disease under lamotrigine therapy. Acta Neurol Scand. 111(6):385-390.
  20. Chiu Elley, Liu CS, Tan TY, Ku CC. (2006)Venturi Mask Adjuvant Oxygen Therapy in Severe Acute Ischemic Stroke Arch Neurol. 63:741-744.
  21. Liu CS, Cheng WL, Lee CF, Ma YS, Lin CY, Huang CC, Wei YH. (2006) Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies. Acta Neurol Scand 2006: 113: 334–341.
  22. Chen Ming, Kuo SJ, Liu CS, Chen WL, Ko TM, Chen TH, Chang SP, Huang CH, Chang YY, Wang BT. (2006) A novel heterozygous missense mutation 377T > C (V126A) of TGIF gene in a family segregated with holoprosencephaly and moyamoya disease. Prenatal Dignosis 2006 26: 226–230.
  23. Lin CL, Kwan AL, Loh JK, Dumont AS, Kuo CL, Wu SC, Luec SI, Huang CS, Jeng AY and Liu CS.* (2007) Attenuation of experimental subarachnoid hemorrhage induced increases in circulating intercellular adhesion molecule? and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303 Journal of Neurosurgery 106(3):442-448.
  24. Chiang MC, Chen HM, Lee Y.H, Chang HH, Wu YC, Soong BW., Chen CM, Wu YR, Liu CS, Niu DM, Wu JY, Chen YT. and Chern YJ (2007) Dysregulation of C/EBP by mutant Huntingtin causes the urea cycle deficiency in Huntington’s disease Human Molecular Genetics 16(5):483-4
  25. Liu CS.*, Chen CH, Chiang HC, Kuo CL, Huang CS, Cheng W.L, Wei YH and Chen HW. (2007) B Group Vitamins, MTHFR C677T Polymorphism and Carotid Intima-Media Thickness in Clinically Healthy Subjects. European Journal of Clinical Nutrition 61(8):996-1003.
  26. Chuang CS, Lo MC, Lee KW, Liu CS*. (2007) Magnetic resonance spectroscopy study in basal ganglia of patients with myoclonic epilepsy with ragged-red fibers. Neurol India 55(4):385-387.
  1. Chen HW, Kuo CL, Huang CS, Kuo SJ, Liu CS*. (2008) Oxidized Low-Density Lipoproteins, Autoantibodies against Oxidized Low-Density Lipoproteins and Carotid Intima Media Thickness in a Clinically Healthy Population. Cardiology 110(4):252-259.
  2. Liu CS*, Cheng WL, Kuo SJ, Li JY, Soong BW, Wei YH.(2008) Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases. J Neurol Sci.15;264(1-2):18-21.
  3. Juo SH, Liao YC, Kuo CL, Wang Y, Huang CS, Chiang HC, Liu CS*. (2008) The MTHFR 677 C/T polymorphism influences plasma levels of adhesion molecules and nitric oxide. Thromb Res. 121(4):549-554.
  4. Lu MK, Shih HT, Huang KJ, Ziemann U, Tsai CH, Chang FC, Chen YC, Lin YT, HuangWS, Lee CC, Liu CS.(2008) Movement-related cortical potentials in patients with Machado-Joseph disease. Clin Neurophysiol.119(5):1010-1019.
  5. Chen SR, Lin KP, Kuo HC, Chen CM, Hsieh ST, Lee MJ, Yang CC, Liu CS, Huang CC, Lyu RK, Ro LS.(2008) Comparison of two PCR-based molecular methods in the diagnosis of CMT 1A and HNPPdiseases in Chinese. Clinical Neurology and Neurosurgery 110:466–471.
  6. Shen M, Zhang L, Bonner MR, Liu CS, Li G, Vermeulen R, Dosemeci M, Yin S, Lan Q. (2008) Association Between Mitochondrial DNA Copy Number, Blood Cell Counts, and Occupational Benzene Exposure. Environmental and Molecular Mutagenesis 49(6):453-457.
  7. Lan Q, Lim U, Liu CS, Weinstein SJ, Chanock S, Bonner MR, Virtamo J, Albanes D, Rothman N. (2008) A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood. 15;112(10):4247-4249.
  8. Ma GC, Liu CS, Chang SP, Yeh KT, Ke YY, Chen TH, Wang BB, Kuo SJ, Shih JC, Chen M. (2008) A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. Prenat Diagn. 28(11):1057-1063.
  9. Bonner MR, Shen M, Liu CS, Divita M, He X, Lan Q.(2009) Mitochondrial DNA content and lung cancer risk in Xuan Wei, China. Lung Cancer. 63(3):331-334.
  10. Lee CH, Lai PH, Liu CS, Li JY. (2009) Proton magnetic resonance spectroscopy in Kennedy disease. J Neurol Sci. 15;277(1-2):71-75.
  11. Lee YC, Liu CS, Chang MH, Lin KP, Fuh JL, Lu YC, Liu YF, Soong BW. (2009) Population-specific spectrum of NOTCH3 mutations, MRI features and founder effect of CADASIL in Chinese. J Neurol. 256(2):249-255.
  12. Lee YC, Liu CS, Wu HM, Wang PS, Chang MH, Soong BW.(2009) The 'hot cross bun' sign in the patients with spinocerebellar ataxia. Eur J Neurol. 16(4):513-516.
  13. Yu YC, Kuo CL, Cheng WL, Liu CS*, Hsieh M. (2009)Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease. J Neurosci Res. 87(8):1884-1891
  14. Sun MJ, Cheng WL, Wei YH, Kuo CL, Sun S, Tsai HD, Lin HM, Liu CS*. (2009)Low copy number and high 4977 deletion of mitochondrial DNA in uterosacral ligaments are associated with pelvic organ prolapse progression. Int Urogynecol J Pelvic Floor Dysfunct. 20:867-872.
  15. Chen M, Kuo HH, Huang YC, Ke YY, Chang SP, Chen CP, Lee DJ, Lee ML, Lee MH, Chen TH, Chen CH, Lin HM, Liu CS, Ma GC. (2009) A case of restrictive dermopathy with complete chorioamniotic membrane separation caused by a novel homozygous nonsense mutation in the ZMPSTE24 gene. Am J Med Genet A. 149:1550-1554.
  16. Jou SH, Chiu NY, Liu CS.* (2009)Mitochondrial dysfunction and psychiatric disorders. Chang Gung Med J. 32:370-379.
  17. Su SL, Jou SH, ChengWL, Lin TT, Li JY, Huang CC, Lee YC, Soong BW, Liu CS*. (2010) Mitochondrial DNA damage in spinal and bulbar muscular atrophy patients and carriers. Clin Chim Acta. 411:626-630
  18. Chuang CS, Su HL, Cheng FC, Hsu SH, Chuang CF, Liu CS*. (2010)Quantitative Evaluation of Motor Function Before and After Engraftment of Dopaminergic Neurons in a Rat Model of Parkinson's Disease. J Biomed Sci. 13;17(1):9.
  19. Liu CS, Lii CK, Chang LL, Kuo CL, Cheng WL, Su SL, Tsai CW, Chen HW. (2010)Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. Nutr Res. 30(2):118-124.
  20. Hosgood HD 3rd, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL, Albanes D, Lan Q. (2010) Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 31(5):847-849.
  21. Chen CW, Liu CS, Chiu IM, Shen SC, Pan HC, Lee KH, Lin SZ, Su HL. (2010)The signals of FGFs on the neurogenesis of embryonic stem cells. J Biomed Sci. 29;17:33.
  22. Chang JC, Kou SJ, Lin WT, Liu.CS*.(2010) Regulatory role of mitochondria in oxidative stress and Atherosclerosis. World J Cardiol. 26; 2(6): 150-159.(non-SCI)
  23.  Tu ST, Wang IW, Lin HF, Liao YC, Lin RT, Liu CS, Hank Juo SH.(2010) Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases. J Investig Med. 58(6):786-790.
  24.  Kuo SJ, Chen M, Ma GC, Chen ST, Chang SP, Lin WY, Chen YC, Lee TH, Lin TT, Liu CS.* (2010) Number of somatic mutations in the mitochondrial D-loop region indicates poor prognosis in breast cancer, independent of TP53 mutation. Cancer Genet Cytogenet.201(2):94-101.
  25. Liu CS, Soong BW, Lee YC, Chen WL, Kuo CL, Cheng WL, Huang CS, Lin WT. (2010) Gluten sensitivity: associated sporadic cerebellar ataxia in taiwan. Acta Neurol Taiwan. 19(4):263-269.(non-SCI)
  26. Tsai HD, Hsieh YY, Hsieh JN, Chang CC, Yang CY, Yang JG, Cheng WL, Tsai FJ, Liu CS*.(2010) Mitochondria DNA deletion and copy numbers of cumulus cells associated with in vitro fertilization outcomes. J Reprod Med.55(11-12):491-7.
  27. Pan HC, Wu YT, Shen SC, Wang CC, Tsai MS, Cheng FC, Lin SZ, Chen CW, Liu CS, Su HL. (2011)Characterization of axon formation in the embryonic stem cell-derived motoneuron. Cell Transplant. 20(4):493-502
  28. Huang CH, Su SL, Hsieh MC, Cheng WL, Chang CC, Wu HL, Kuo CL, Lin TT, Liu CS*. (2011)Depleted leukocyte mitochondrial DNA copy number in metabolic syndrome. Journal of Atherosclerosis and Thrombosis.18:867-873
  29. Chen CY, Chen HF, Gi SJ, Chi TH, Cheng CK, Hsu CF, Ma YS, Wei YH, Liu CS, Hsieh M.(2011) Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation. Mitochondrion. 11:739-749.
  30. Tsai TL, Liu CS, Lai CH.(2011) Nationwide population-based epidemiologic study on cerebellar ataxia in Taiwan. Eur Neurol. 66(4):215-219.
  31. Lynch S, Weinstein S, Virtamo J, Lan Q, Liu CS, Cheng WL, Rothman N, Albanes D, Stolzenberg-Solomon R.(2011) Mitochondrial DNA copy number and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention (ATBC) Study. Cancer Prev Res (Phila). 4:1912-1919
  32. Liu CS, Chang CC, Du YC, Chang FR, Wu YC, Chang WC, Hsieh TJ. 2-hydroxy-4'-methoxychalcone inhibits proliferation and inflammation of human aortic smooth muscle cells by increasing the expression of peroxisome proliferator-activated receptor gamma. J Cardiovasc Pharmacol.2012; 59(4):339-351.
  33. Lee YC, Liu CS, Lee TY, Lo YC, Lu YC, Soong BW. SCA31 is rare in the Chinese population on Taiwan. Neurobiology of Aging. 2012;33 (426).e23– e24
  34. Tsai JD, Liu CS, Tsao TF, Sheu JN. A novel mitochondrial dna 8597T>C mutation of leigh syndrome: report of one case. Pediatrics and Neonatology. 2012;53:60-62
  35. Lin CS, Wang LS, Chang SC, Chou TY, Hsu WH, Liu CS, Lee MH, Chung MY, Wei YH. Associated microsatellite alterations in mitochondrial DNA and in TP53 in thoracic esophageal squamous cell carcinoma. Oncol Rep.2012; 28(1):69-76.
  36. Yeang CH, Ma GC, Shih JC, Yang YS, Chen CP, Chang SP, Wu SH, Liu CS, Kuo SJ, Chou HC, Hwu WL, Cameron AD, Ginsberg NA, Lin YS, Chen M. Genome-wide gene expression analysis implicates the immune response and lymphangiogenesis in the pathogenesis of fetal chylothorax. PLoS One.2012; 7(4):e34901.
  37. Yu SC, Kuo CL, Huang CS, Chang CS, Wu SL, Su SL, Liu CS*. Endogenous granulocyte colony-stimulating factor: a biomarker in acute ischemic stroke. Biomarkers.2012;17(4):319-324.
  38. Chen CY, Chen YL, Chiu CM, Chiang JY, Liu CS, Lo LC.Spinocerebellar ataxia treated with combination of traditional Chinese medicine and western medicine-case report. J Chin Med.2012; 23(1):93-102.(non-SCI)
  39. Yen HH, Shih KL, Lin TT, Su WW, Soon MS, Liu CS*. Decreased mitochondrial deoxyribonucleic acid and increased oxidative damage in chronic hepatitis C. World J Gastroenterol. 2012;28;18(36):5084-5089.
  40. Su SL, Wang WF, Wu SL, Wu HM, Chang JC, Huang CS, Cheng WL, Soong BW, Lee YC, Li JY, Kuo SJ, Chen M, Huang CN, Liu CS*. FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease. Clinica Chimica Acta 2012;414:225-227. 
  41. Chang JC, Liu KH, Li YC, Kou SJ, Wei YH, Chuang CS, Hsieh ML, Liu CS*. Functional recovery of human cells harbouring the mitochondrial DNA mutation MERRF A8344G via peptide-mediated mitochondrial delivery. NeuroSignals.2013; 21:160-173.
  42. Fu SC, Kuo HC, Chu CC, Wu YR, Ro LS, Liu CS, Huang CC. Long-term follow-up of spinal and bulbar muscular atrophy in Taiwan. J Formos Med Assoc.2013;112(6):326-331.
  43. Chen CC, Liu CS, Li CC, Tsai CW, Yao HT, Liu TC, Lii CK, Chen PY, Wu YL, Chen HW, Liu KL. Indigofera suffruticosa Mill extracts up-regulate the expression of the π class of glutathione S-transferase and NAD(P)H: Quinone oxidoreductase 1 in rat Clone 9 liver cells. Food Chem Toxicol. 2013;59:610–617.
  44. Chang CS, Su SL, Chang CC, Lee KW, Kuo CL, Huang CS, Tseng WM, Liu CS*.Cyclophilin A: a novel biomarker for untreated male essential hypertension. Biomarkers. 2013;18(8):716-720.
  45. Huang CH, Chang CC, Huang CS, Kuo CL, Chen CP, Hsia CH, Chang YM, Chen HT, Feng CC, Lin LS, Yang PT, Tsai CD, Lin CS, Liu CS*. Using oxidized low-density lipoprotein autoantibodies to predict restenosis after balloon angioplasty in patients with acute myocardial infarction. PLoS One.2013; 8(10):e74
  46. Lin CJ, Wang SC, Ku CL, Kao JK, Chen M, Liu CS. Successful unrelated cord blood stem cell transplantation in an X-linked chronic granulomatous disease patient with disseminated BCG-induced infection. Pediatr Neonatol.2013; May 13. pii: S1875-9572(13)00070-3.
  47. Chang JC, Liu KH, Chuang CS, Su HL, Wei YH, Kuo SJ, Liu CS*. Treatment of human cells derived from MERRF syndrome by peptide-mediated mitochondrial delivery. Cytotherapy. 2013;15(12):1580-1596.
  48. Liu CS*, Wu SL, Cheng WL, Lin TT, Jhang KM, Kuo SJ. Family migraine with mitochondrial DNA A3111T mutation . The Changhua Journal of Medicine, 2013;11(1),63-67.(non-SCI)
  49. Chang JC, Liu KH, Chuang CS, WuSL, Kuo SJ, Liu CS*. Transplantation of Pep-1-labeled mitochondria protection against a 6-OHDAinduced neurotoxicity in rats . The Changhua Journal of Medicine,2013; 11(1),8-17. (non-SCI)
  50. Su SL, Kuo CL, Huang CS, Liu CS*. Fibroblast growth factor 21 predicts type 2 diabetes in Taiwanese . The Changhua Journal of Medicine, 2013;11(1),42-47. (non-SCI)
  51. Chen YH, Lin WW, Liu CS, Hsu LS, Lin YM, Su SL. Caveolin-1 palliates renal oxidative damage in hypercholesterolemic rabbits. The Changhua Journal of Medicine, 2013;11(1),18-25. (non-SCI)
  52. Lee YL, Liu CE, Cho WL, Kuo CL, Cheng WL, Huang CS, Liu CS*. Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults. Biomarkers.2014; 19(2):109-113.
  53. Chen YH, Lin WW, Liu CS, Hsu LS, Lin YM, Su SL. Caveolin-1 provides palliation for adverse hepatic reactions in hypercholesterolaemic rabbits. PLoS One. 2014;24;9(1):e71862.
  54. Hofmann JN, Hosgood HD 3rd, Liu CS, Chow WH, Shuch B, Cheng WL, Lin TT, Moore LE, Lan Q, Rothman N, Purdue MP. A nested case-control study of leukocyte mitochondrial DNA copy number and renal cell carcinoma in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Carcinogenesis. 2014;35(5):1028-1031.
  55. Chang CC, Jou SH, Lin TT, Liu CS*. Mitochondria DNA variation and increased oxidative damage in euthymic patients with bipolar disorder. Psychiatry Clin Neurosci. 2014;68(7):551-557.
  56. Jhang KM, Chang TM, Chen M, Liu CS*. Generalized epilepsy in a patient with mosaic Turner syndrome: a case report. J Med Case Rep.2014; 2;8(1):109. (non-SCI)
  57. Chien JW, Wang LY, Cheng YS, Tsai YG, Liu CS*. Urinary 8-hydroxy-2'-deoxyguanosine (8-oxodG) level can predict acute renal damage in young children with urinary tract infection. Biomarkers. 2014;19(4):326-331.
  58. Hofmann JN, Hutchinson AA, Cawthon R, Liu CS, Lynch SM, Lan Q, Rothman N, Stolzenberg-Solomon R, Purdue MP. Telomere length varies by DNA extraction method: implications for epidemiologic research-letter. Cancer Epidemiol Biomarkers Prev. 2014;23(6):1129-1130.
  59. Liu CS*, Chang JC, Kuo SJ, Liu KH, Lin TT, Cheng WL, Chuang SF. Delivering healthy mitochondria for the therapy of mitochondrial diseases and beyond. Int J Biochem Cell Biol.2014; 53C:141-146.
  60. Hosnijeh FS, Lan Q, Rothman N, Liu CS, Cheng WL, Nieters A, Guldberg P, Tjønneland A, Campa D, Martino A, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Krogh V, Tumino R, Panico S, Masala G, Weiderpass E, Huerta Castaño JM, Ardanaz E, Sala N, Dorronsoro M, Quirós JR, Sánchez MJ, Melin B, Johansson AS, Malm J, Borgquist S, Peeters PH, Bueno-de-Mesquita HB, Wareham N, Khaw KT, Travis RC, Brennan P, Siddiq A, Riboli E, Vineis P, Vermeulen R. Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort. Blood. 2014;24;124(4):530-535.
  61. Chung WH, Chang WC, Lee YS, Wu YY, Yang CH, Ho HC, Chen MJ, Lin JY, Hui RC, Ho JC, Wu WM, Chen TJ, Wu T, Wu YR, Hsih MS, Tu PH, Chang CN, Hsu CN, Wu TL, Choon SE, Hsu CK, Chen DY, Liu CS, Lin CY, Kaniwa N, Saito Y, Takahashi Y, Nakamura R, Azukizawa H, Shi Y, Wang TH, Chuang SS, Tsai SF, Chang CJ, Chang YS, Hung SI; Taiwan Severe Cutaneous Adverse Reaction Consortium; Japan Pharmacogenomics Data Science Consortium. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions. JAMA. 2014;6;312(5):525-534.
  62. Huang CH, Chang CC, Kuo CL, Huang CS, Chiu TW, Lin CS, Liu CS*. Serum iron concentration, but not hemoglobin, correlates with TIMI risk score and 6-month left ventricular performance after primary angioplasty for acute myocardial infarction. PLoS One. 2014 Aug 6;9(8):e104495.
  63. Kim C, Bassig BA, Seow WJ, Hu W, Purdue MP, Shu XO, Huang WY, Liu CS, Cheng WL, Lin TT, Xiang YB, Ji BT, Gao YT, Chow WH, Mannisto S, Weinstein SJ, Albanes D, Zheng W, Hosgood HD, Lim U, Rothman N, Lan Q. Pooled analysis of mitochondrial DNA copy number and lung cancer risk in three prospective studies. Cancer Epidemiol Biomarkers Prev. 2014;23(12):2977-2980
  64. Hyland PL, Pfeiffer RM, Rotunno M, Hofmann JN, Liu CS, Cheng WL, Yuenger J, Lan Q, Tucker MA, Goldstein AM, Yang XR. Constitutive mitochondrial DNA copy number in peripheral blood of melanoma families with and without CDKN2A mutations. J Carcinog Mutagen 2014, S4:S4.(non-SCI)
  65. Kim C, Bassig BA, Seow WJ, Hu W, Purdue MP, Huang WY, Liu CS, Cheng WL, Mannisto S, Vermeulen R, Weinstein SJ, Lim U, Hosgood HD, Bonner MR, Caporaso NE, Albanes D, Lan Q, Rothman N. Mitochondrial DNA copy number and chronic lymphocytic leukemia/small lymphocytic lymphoma risk in two prospective studies. Cancer Epidemiol Biomarkers Prev. 2015;24(1):148-153.
  66. Huang CH, Chang CC, Kuo CL, Huang CS, Lin CS, Liu CS*.Decrease in plasma cyclophilin A concentration at 1 month after myocardial infarction predicts better left ventricular performance and synchronicity at 6 months: A pilot study in patients with ST elevation myocardial infarction. International Journal of Biological Sciences. 2015;11(1): 38-47.
  67. Chang CC, Jou SH, Lin TT, Lai TJ, Liu CS*. Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder. PLoS One. 2015 May 6;10(5):e0125855.
  68. Kao HW, Lee KW, Kuo CL, Huang CS, Tseng WM, Liu CS, Lin CP. Interleukin-6 as a prognostic biomarker in ruptured intracranial aneurysms. PLoS One.2015 Jul 15;10(7):e0132115.
  69. Lin CJ, Lin HJ, Chen TH, Hsu YA, Liu CS, Hwang GY, Wan L. Correction: Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression. PLoS One. 2015 Apr 10;10(4):e0125288.
  70. Chen YT, Chen WL, Chen SN, Liu CS*.Brain stem lesion in mitochondrial DNA G11778A mutation of Leber's hereditary optic neuropathy. J Formos Med Assoc. 2015 Jul;114(7):668-669
  71. Kao HW, Lee KW, Chen WL, Kuo CL, Huang CS, Tseng WM, Liu CS*, Lin CP. Cyclophilin A in ruptured intracranial aneurysm: A Prognostic Biomarker. Medicine (Baltimore). 2015;Sep;94(39):e1683.
  72. Tsai SF, Su CW, Wu MJ, Chen CH, Fu CP, Liu CS, Hsieh M. Urinary cyclophilin A as a new marker for diabetic nephropathy: A cross-sectional analysis of diabetes mellitus. Medicine (Baltimore). 2015 Oct;94(42):e1802. doi:10.1097/MD.0000000000001802.
  73. Tsai JD, Tsai HJ, Wei CC, Liu CS, Yang SH, Sheu JN. Recurrent Childhood Stroke-like Episodes. Acta Neurol Taiwan. 2015 Dec;24(4):133-134.(non-SCI)
  74. Wang TK, Lin YM, Lo CM, Tang CH, Teng CL, Chao WT, Wu MH, Liu CS, Hsieh M. Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells. Tumour Biol. 2016 Jun;37(6):7989-8005.
  75. Sun MJ, Cheng YS, Sun R, Cheng WL, Liu CS. Changes in mitochondrial DNA copy number and extracellular matrix (ECM) proteins in the uterosacral ligaments of premenopausal women with pelvic organ prolapse. Taiwan J Obstet Gynecol. 2016 Feb;55(1):9-15.
  76. Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS*. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res. 2016 Apr;170:40-56.
  77. Huang PJ, Kuo CC, Lee HC, Shen CI, Cheng FC, Wu SF, Chang JC, Pan HC, Lin SZ, Liu CS*, Su HL. Transferring xenogenic mitochondria provides neural protection against ischemic stress in ischemic rat brains. Cell Transplant. 2016;25(5):913-27.
  78. Chen YH, Lin WW, Liu CS, Hsu LS, Lin YM, Su SL. Caveolin-1 Expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia. PLoS One. 2016 Apr 28;11(4):e0154210.
  79. Lin HC, Su SL, Lu CY, Lin AH, Lin WC, Liu CS, Yang YC, Wang HM, Lii CK, Chen HW. Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells. Environ Toxicol. 2017 Mar;32(3):918-930.
  80. Chang JC, Wu SL, Hoel F, Cheng YS, Liu KH, Hsieh M, Hoel A, Tronstad KJ, Yan KC, Hsieh CL, Lin WY, Kuo SJ, Su SL, Liu CS*. Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. Sci Rep. 2016 Jul 29;6:30436. doi: 10.1038/srep30436. PubMed PMID: 27469193.
  81. Huang CH, Kuo CL, Huang CS, Tseng WM, Lian IeB, Chang CC, Liu CS*. High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction. Medicine (Baltimore). 2016 Aug;95(31):e4501. doi: 10.1097/MD.0000000000004501. PubMed PMID: 27495100.
  82. Chen PY, Sun HL Lin YC, Li CC, Chen HW, Wang TS, Liu CS*, Liu KL. 18-Carbon polyunsaturated fatty acids via down regulation NF-kB activation reduce lipopolysaccharide-induced myotube atrophy. RSC Adv;2016,6, 23581-23587.
  83. Chen YH, Chen YC, Liu CS, Hsieh MC. The different effects of atorvastatin and pravastatin on cell death and PARP activity in pancreatic NIT-1 Cells. J Diabetes Res. 2016;2016:1828071.
  84. Chen PY, Liu CS, Lin LY, Lin YC, Sun HL, Li CC, Chen HW, Wang TS, Wang J, Liu KL. Borage oil supplementation decreases lipopolysaccharide-induced inflammation and skeletal muscle wasting in mice.RSC Adv., 2016,6, 100174-100185
  85. Wu IC, Lin CC, Liu CS, Hsu CC, Chen CY, Hsiung CA. Interrelations between mitochondrial DNA copy number and inflammation in older adults. J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):937-944.
  86. Moore A, Lan Q, Hofmann JN, Liu CS, Cheng WL, Lin TT, Berndt SI. A prospective study of mitochondrial DNA copy number and the risk of prostate cancer. Cancer Causes Control. 2017 Jun;28(6):529-538.
  87. Liu PT, Chiu CM, Liu CS, Wei TS, Lai TC. Tai Chi training improves balance control in patients with spinocerebellar ataxia. The Changhua Journal of Medicine 2016;14:205-212.(non-SCI)
  88. Liu CS*, Hsiao CC, KuoCL, Chiu CM,, Cheng WL, Kuo CC, Huang Lin LC, Lin LC, , Hui-Ju Chang HJ, Li HW, Deng LC, Chang JC, Lo LC, Liu PT, Wei TS. Impact of holistic care with tai chi exercise on depressed patients with spinocerebellar degeneration disease- pilot study. The Changhua Journal of Medicine 2016;14:179-186.(non-SCI)
  89. Huang CH, Kuo CL, Huang CS, Liu CS, Chang CC. Depleted leukocyte mitochondrial DNA copy number correlates with unfavorable left ventricular volumetric and spherical shape remodeling in acute myocardial infarction after primary angioplasty. Circ J. 2017 Nov 24;81(12):1901-1910.
  90. Chang JC, Hoel F, Liu KH, Wei YH, Cheng FC, Kuo SJ, Tronstad KJ, Liu CS*. Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation. Sci Rep. 2017 Sep 6;7(1):10710.
  91. Chung TW, Li YR, Huang WY, Su JH, Chan HL, Lin SH, Liu CS, Lin SC, Lin CC, Lin CH. Sinulariolide suppresses LPS?induced phenotypic and functional maturation of dendritic cells. Mol Med Rep. 2017 Nov;16(5):6992-7000.
  92. Wong JYY, Hu W, Downward GS, Seow WJ, Bassig BA, Ji BT, Wei F, Wu G, Li J, He J, Liu CS, Cheng WL, Huang Y, Yang K, Chen Y, Rothman N, Vermeulen RC, Lan Q. Personal exposure to fine particulate matter and benzo[a]pyrene from indoor air pollution and leukocyte mitochondrial DNA copy number in rural China. Carcinogenesis. 2017 Sep 1;38(9):893-899.
  93. Wu YL, Chang JC, Lin WY, Li CC, Hsieh M, Chen HW, Wang TS, Liu CS*, Liu KL. Treatment with caffeic acid and resveratrol alleviates oxidative stress induced neurotoxicity in cell and drosophila models of spinocerebellar ataxia type3. Sci Rep. 2017 Sep 14;7(1):11641. doi: 10.1038/s41598-017-11839-0. PubMed PMID: 28912527.
  94. Chen YH, Lin WW, Liu CS, Su SL. H2O2 induces caveolin?1 degradation and impaired mitochondrial function in E11 podocytes. Mol Med Rep. 2017 Nov;16(5):7841-7847.
  95. Chuang CS, Chang JC, Cheng FC, Liu KH, Su HL, Liu CS*. Modulation of mitochondrial dynamics by treadmill training to improve gait and mitochondrial deficiency in a rat model of Parkinson's disease. Life Sci. 2017 Dec 15;191:236-244.
  96. Chang JC, Yeh CY, Chang TL, Liu KH, Soong BW, Hsieh ML, Chang T, Liu CS*. In vivo and In vitro Studies of Mitochondrial Transplantation for the Treatment of Spinocerebellar Ataxia Type 3. The Changhua Journal of Medicine 2017;15.(non-SCI)
  97. Wu YL, Chang JC, Lin WY, Li CC, Hsieh M, Chen HW, Wang TS, Wu WT, Liu CS*, Liu KL. Caffeic Acid and Resveratrol Ameliorate Cellular Damage in Cell and Drosophila Models of Spinocerebellar Ataxia Type 3 through Upregulation of Nrf2 Pathway. Free Radic Biol Med. 2017 Dec 13;115:309-317.
  98. Liu SW, Chang JC, Chuang SF, Liu KH, Cheng WL, Chang HJ, Chang HS, Lin TT, Hsieh CL, Lin WY, Hsieh M, Kuo SJ, Liu CS*. Far-infrared Radiation Improves Motor Dysfunction and Neuropathology in Spinocerebellar Ataxia Type 3 Mice. Cerebellum. 2018 May 3. doi: 10.1007/ s12311-018-0936-3.
  99. Chang CS, Su SL, Kuo CL, Huang CS, Tseng WM, Lin SS, Liu CS*. Cyclophilin A: A predictive biomarker of carotid stenosis in cerebral ischemic stroke. Curr Neurovasc Res. 2018; 15(2):111-119. 126.
  100. Chen YT, Chen SN, Liu CS*. The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan. Taiwan J Ophthalmol. 2018 Apr-Jun;8(2):82-86.(non-SCI)
  101. Ou YH, Chen AW, Fan JY, Cheng WL, Lin TT, Chen MK, Liu CS*. Aminoglycoside-associated nonsyndromic deafness and speech disorder in mitochondrial A1555G mutation in a family: A case report. Medicine (Baltimore). 2018 Oct;97(42):e12878. doi: 10.1097/MD.0000000000012878. PubMed PMID: 30335006.
  102. Chen AW, Wu SL, Cheng WL, Chuang CS, Chen CH, Chen MK, Liu CS*. Dysphagia with fatal choking in oculopharyngeal muscular dystrophy: Case report. Medicine (Baltimore). 2018 Oct;97(43):e12935. doi: 10.1097/MD.0000000000012935. PubMed PMID: 30412104.
  103. Chiu PF, Su SL, Tsai CC, Wu CL, Kuo CL, Kor CT, Chang CC, Liu CS*. Cyclophilin A and CD147 associate with progression of diabetic nephropathy. Free Radic Res. 2018 Dec 20:1-8. doi: 10.1080/10715762.
  104. Su SL, Kuo CL, Chien-Wei Su CW, Huang CS, Tseng WM, Hsieh ML, Liu CS*. Secreted Cyclophilin A Is an Inflammatory Marker in Patients With Diabetic Nephropathy. The Changhua Journal of Medicine 2018;16:143-151.
  105. Chang JC, Chang HS, Wu YC, Cheng WL, Lin TT, Chang HJ, Kuo SJ, Chen ST, Liu CS. Mitochondrial transplantation regulates antitumour activity, chemoresistanceand mitochondrial dynamics in breast cancer. J Exp Clin Cancer Res. 2019 Jan 23;38(1):30. doi: 10.1186/s13046-019-1028-z. 

Books.

1.Liu CS. Handbook of Vitamin C Research: Daily Requirements, Dietary Sources and Adverse Effects.P.127-152.

 

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